Chroogomphus rutilus Prevents Periodontal Bone Loss during Orthodontic Tooth Movement in Osteoporotic Rats by Regulating Bone Metabolism

Osteoporosis (OP) can aggravate periodontal bone loss during orthodontic treatment. Chroogomphus rutilus (CR) is rich in nutrients and exhibits antioxidant and anti-inflammatory activities. In this study, the components of CR were systematically examined firstly, and then its regulatory effects on bone metabolism to prevent bone loss during orthodontic tooth movement (OTM) in osteoporotic rats were investigated. The results of imaging tests revealed that CR reduced periodontal bone loss and normalized tooth movement in the OP. Combined with intestinal flora and metabolomic analyses, CR up-regulates the abundance of anti-inflammatory genera such as Bacteroides and Alistipes, while reducing the production of inflammatory metabolites, such as glycerophospholipids.