Bicd2

Enables several functions, including dynactin binding activity; dynein complex binding activity; and dynein light intermediate chain binding activity. Involved in several processes, including microtubule anchoring at microtubule organizing center; minus-end-directed organelle transport along microtubule; and retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum. Acts upstream of or within microtubule-based movement. Located in Golgi apparatus and cytoplasmic vesicle. Is expressed in several structures, including central nervous system; dorsal root ganglion; olfactory epithelium; and retina. Human ortholog(s) of this gene implicated in spinal muscular atrophy with lower extremity predominant 2A and spinal muscular atrophy with lower extremity predominant 2B. Orthologous to human BICD2 (BICD cargo adaptor 2). [provided by Alliance of Genome Resources, Nov 2024]

该数据集包含多种功能，包括动粒蛋白结合活性、动力蛋白复合物结合活性和动力蛋白轻链结合活性。参与多种过程，例如微管组织中心处的微管锚定、沿微管进行的负端定向细胞器运输以及逆向囊泡介导的运输，从高尔基体到内质网的运输。在基于微管的运动中起到上游或内部的作用。位于高尔基体和细胞质囊泡中。在多个结构中表达，包括中枢神经系统、背根神经节、嗅觉上皮和视网膜。该基因的人类同源基因与下肢为主的脊髓肌肉萎缩症2A型和下肢为主的脊髓肌肉萎缩症2B型有关。与人类BICD2（BICD货物适配器2）同源。[由基因组资源联盟提供，2024年11月]