Gene expression profile at single cell level of adrenal glands from the Tmem127 wild type (WT) and knocked out (KO) mice

Tmem127 is a tumor suppressor gene that has been linked to inherited susceptibility to pheochromocytomas. We used single nuclei RNA sequencing (snRNA-seq) to explore the cellular role of Tmem127. Nuclei from 6 pairs frozen adrenal glands were extracted and isolated by Fluorescence-activated cell sorting (FACS) according to the DPI signal and analyzed using snRNAseq.