Solution structure of the MYND domain from AML1-ETO complexed with SMRT, a corepressor Descriptor: Protein CBFA2T1, SMRT, ZINC ION Authors: Liu, Y.Z, Chen, W, Gaudet, J, Cheney, M.D, Roudaia, L, Cierp
Transcription by RNA polymerase II is accompanied by cyclic phosphorylation and dephosphorylation of the carboxy-terminal heptapeptide repeat domain (CTD) of its largest subunit. We have used deletion
In thymus hematopoietic precursor cells differentiate into aà T cells, ?d T cells, mucosa-associated invariant T cells (MAIT), and natural killer T (NKT) cells. We show that both ablation of NFATc1 o
The Mediator complex directs signals from DNA-binding transcription factors to RNA polymerase (Pol) II. Despite this pivotal position, mechanistic understanding of Mediator in human cells remains inco
