Additional file 2 of Tracheal, bronchus, and lung cancer among older adults: thirty-year global burden trends, precision medicine breakthroughs, and lingering barriers

Supplementary Material 2: Figure S1. Association between older TBL cancer patients (aged 70 years and older) with ASIRs, ASDRs, and ASMRs and SDIs in 204 countries and territories from 1990 to 2021. SDI vs ASIRs: (A) both sexes, (B) males, (C) females; SDI vs ASMRs: (D) both sexes, (E) males, (F) females; SDI vs ASDRs: (G) both sexes, (H) males, (I) females. Abbreviations: ASIR = age-standardized incidence rate, ASMR = age-standardized mortality rate, ASDR = age-standardized rate of DALYs, DALYs = disability-adjusted life years, SDI = sociodemographic index, TBL = tracheal, bronchial, and lung. Figure S2. AAPCs of the ASIR (A), ASMR (B), and ASDR (C) from 1990 to 2021 in 204 countries and territories according to the SDI in 2021. Abbreviations: ASIR = age-standardized incidence rate, ASMR = age-standardized mortality rate, ASDR = age-standardized rate of DALYs, AAPCs = average annual percent changes, DALYs = disability-adjusted life years, SDI = sociodemographic index, TBL = tracheal, bronchial, and lung. Figure S3. Comparison of the ASIR, ASMR, and ASDR for older TBL cancer patients (aged 70 years and older) in both sexes across 21 geographical GBD regions by the SDI for 1990, 2004, 2015 and 2021. (A) ASIR, (B) ASMR, (C) ASDR. Abbreviations: ASIRs = age-standardized incidence rate, ASMRs = age-standardized mortality rate, ASDRs = age-standardized rate of DALYs, DALYs = disability-adjusted life years, GBD = global burden of disease, SDI = socialdemographic index, TBL = tracheal, bronchial, and lung. Figure S4. Comparison of the ASIR, ASMR, and ASDR for older TBL cancer patients (aged 70 years and older) in male across 21 geographical GBD regions by the SDI for 1990, 2004, 2015 and 2021. (A) ASIR, (B) ASMR, (C) ASDR. Abbreviations: ASIRs = age-standardized incidence rate, ASMRs = age-standardized mortality rate, ASDRs = age-standardized rate of DALYs, DALYs = disability-adjusted life years, GBD = global burden of disease, SDI = socialdemographic index, TBL = tracheal, bronchial, and lung. Figure S5. Comparison of the ASIR, ASMR, and ASDR for older TBL cancer patients (aged 70 years and older) in female across 21 geographical GBD regions by the SDI for 1990, 2004, 2015 and 2021. (A) ASIR, (B) ASMR, (C) ASDR. Abbreviations: ASIRs = age-standardized incidence rate, ASMRs = age-standardized mortality rate, ASDRs = age-standardized rate of DALYs, DALYs = disability-adjusted life years, GBD = global burden of disease, SDI = socialdemographic index, TBL = tracheal, bronchial, and lung. Figure S6. The global distribution of the ASIR, ASMR, and ASDR of TBL cancer in older male patients (aged 70 years and older) in 1990 and 2021. Global maps of ASIR (A), ASMR (B), and ASDR (C) in 1990; and global maps of ASIR (D), ASMR (E), and ASDR (F) in 2021. Abbreviations: ASIR = age-standardized incidence rate, ASMR = age-standardized mortality rate, ASDR = age-standardized rate of DALYs, DALYs = disability-adjusted life years, TBL = tracheal, bronchial, and lung. Figure S7. The global distribution of the ASIR, ASMR, and ASDR of TBL cancer in older female patients (aged 70 years and older) in 1990 and 2021. Global maps of ASIR (A), ASMR (B), and ASDR (C) in 1990; and global maps of ASIR (D), ASMR (E), and ASDR (F) in 2021. Abbreviations: ASIR = age-standardized incidence rate, ASMR = age-standardized mortality rate, ASDR = age-standardized rate of DALYs, DALYs = disability-adjusted life years, TBL = tracheal, bronchial, and lung. Figure S8. Proportion of TBL cancer in both sexes older patients (aged 70 years and older) DALYs attributable to 16 risk factors globally and classified by SDI levels in 2021. Abbreviations: DALYs = disability-adjusted life years, TBL = tracheal, bronchial, and lung, SDI = sociodemographic index. Figure S9. Proportion of TBL cancer in older male patients (aged 70 years and older) DALYs attributable to 16 risk factors globally and classified by SDI levels in 2021. Abbreviations: DALYs = disability-adjusted life years, TBL = tracheal, bronchial, and lung, SDI = sociodemographic index. Figure S10. Proportion of TBL cancer in older female patients (aged 70 years and older) DALYs attributable to 16 risk factors globally and classified by SDI levels in 2021. Abbreviations: DALYs = disability-adjusted life years, TBL = tracheal, bronchial, and lung, SDI = sociodemographic index. Figure S11. Global ASIR, ASMR and ASDR for TBL cancer among older patients for both sexes by SDI, 1990-2021. Abbreviations: ASIR = age-standardized incidence rate, ASMR = age-standardized mortality rate, ASDR = age-standardized rate of DALYs, DALYs = disability-adjusted life years, TBL = tracheal, bronchial, and lung, SDI = sociodemographic index. Figure S12. Association between SDI and the proportions of DALYs attributable to 16 risk factors for TBL cancer among older patients for both sexes in 21 GBD regions, 2021. Abbreviations: DALYs = disability-adjusted life years, TBL = tracheal, bronchial, and lung, SDI = sociodemographic index, GBD = global burden of disease. Figure S13. Global ASIR, ASMR and ASDR for TBL cancer among older patients for female by SDI, 1990-2021. Abbreviations: ASIR = age-standardized incidence rate, ASMR = age-standardized mortality rate, ASDR = age-standardized rate of DALYs, DALYs = disability-adjusted life years, TBL = tracheal, bronchial, and lung, SDI = sociodemographic index. Figure S14. Global ASIR, ASMR and ASDR for TBL cancer among older patients for male by SDI, 1990-2021. Abbreviations: ASIR = age-standardized incidence rate, ASMR = age-standardized mortality rate, ASDR = age-standardized rate of DALYs, DALYs = disability-adjusted life years, TBL = tracheal, bronchial, and lung, SDI = sociodemographic index. Figure S15. Association between SDI and the proportions of DALYs attributable to 16 risk factors for TBL cancer among older patients for male in 21 GBD regions, 2021. Abbreviations: DALYs = disability-adjusted life years, TBL = tracheal, bronchial, and lung, SDI = sociodemographic index, GBD = global burden of disease. Figure S16. Association between SDI and the proportions of DALYs attributable to 16 risk factors for TBL cancer among older patients for female in 21 GBD regions, 2021. Abbreviations: DALYs = disability-adjusted life years, TBL = tracheal, bronchial, and lung, SDI = sociodemographic index, GBD = global burden of disease.