The effect of the solvent on paclitaxel extraction efficiency from poly (lactide-co-glycolide) nonwovens

<p>Electrospun (ES) nanofibers may be a promising platform for the delivery of paclitaxel (PTX), because they provide a high surface area to volume ratio, controllable pore sizes and the tunable drug release profiles. The aim of the study was to compare several solvents used in the extraction procedure of PTX from ES poly(D,L-lactide-co-glycolide) (PDLGA) nonwovens. Although the extraction process is crucial for evaluation of the efficacy of drug incorporation into delivery system and during drug release study to evaluate the amount of remaining drug, the reliable method for PDLGA polymeric materials has not been developed so far. The obtained results enabled to select solvents providing efficient extraction of PTX.</p>