Manifestations of gene expression profiles in human right atrial myocardium caused by mechanical stretch

Analysis of gene expression patterns in enlarged left atrial appendage (LAA) in mitral/aortic valve replacement or coronary artery bypass graft surgery can help to identify a comprehensive panel of gene biomarkers for predicting clinical outcomes and to discover potential new therapeutic targets. However, the transcriptional profiles triggered by extended mechanical stretch in cardiac myocytes are not fully understood. Here we performed the first genome-wide study of gene expression changes in human enlarged left atium, resulting in 335 differentially expressed (> 2-fold, P < 0,05) genes in response to mechanical stretch. The study was approved by the ethics committees of Japanese Red Cross KUMAMOTO Hospital. Clinical data of the patients and those tissues were from 11 patients with enlarged left atrium (enlarged LA group) and 10 patients in normal size of atrium. (normal LA group)