A Role for IFITM3 in Regulating Fibrinogen Endocytosis and Platelet Reactivity in Non-Viral Sepsis

Platelets and megakaryocytes are critical players in immune responses. Recent reports suggest infection and inflammation alter the megakaryocyte and platelet transcriptome to induce altered platelet reactivity. We examined if non-viral sepsis induces differential platelet gene expression and reactivity. Non-viral sepsis significantly upregulated IFITM3, an interferon responsive gene that restricts viral replication 6 healthy donors and 6 non-viral sepsis patients