Transcriptomic and epigenetic profiling of fibroblasts in Idiopathic Pulmonary Fibrosis (IPF). Transcriptomic and epigenetic profiling of fibroblasts in Idiopathic Pulmonary Fibrosis (IPF)

ATAC-Seq was applied to identify differentially accessible regions within the genome between healthy and IPF fibroblasts. Overall design: We have used ATAC-Seq on upper lobe cultured fibroblasts from 3 healthy controls and 3 IPF patients to identify differentially accessible regions and transcription factor binding sites within the genome of these cells