FAM111B contributes to the growth of lung adenocarcinoma with KRAS mutation by degrading p16 and promoting cell cycle.

Lung cancer is one of the most common cancers and remains a major worldwide health problem. Lung adenocarcinoma (LUAD) is the major subtype of lung cancer. Although several treatments for LUAD have been developed, still many patients lead to cancer-associated death because of uncontrollable LUAD progression. Further biological and clinical studies to elucidate molecular mechanisms associated with LUAD progression are required to resolve such problems. In this study, we screened family with sequence similarity 111 member B (FAM111B), of which precise functional role in cancers is not clear, as the molecule highly expressed in papillary predominant lung adenocarcinoma. Overall design: We performed RNA sequencing analysis using human FFPE tissue specimens to compare gene expression of lepidic predominant adenocarcinoma with that of papillary predominant adenocarcinoma.