Clinical details of the 19 HOXB13 missense mutation G84E carriers (rs138213197), their male relatives and their mothers at baseline, sufficient to calculate the penetrance estimates.*

*B, brother; F, father; HB, half-brother; MU, maternal uncle; MGF, maternal grandfather; PU, paternal uncle; PGF, paternal grandfather; S, son.Observation time began at date of birth and ended at the earliest of the following: date of diagnosis of prostate cancer, date at death, or 31 Dec 2011. Carrier status: + carrier, (+) obligate carrier, − non-carrier, ? unknown carrier status.