Comparison of gene expression profiles between Dock8+/– and Dock8–/– (tcr)AND Tg DRG (dorsal root ganglion) neurons

To examine the genes involved in IL-31-evoked itch sensation, we employed microarray expression profiling and found that 698 genes were expressed at higher levels in the DRG neurons of Dock8–/– (tcr)AND Tg mice (high IL-31 level) than those of Dock8+/– controls (low IL-31 level). DRG neurons from Dock8+/– and Dock8–/– (tcr)AND Tg mice were isolated, and their gene expression profiles were compared.