Synthesis of 8<i>H</i>‑Indolo[3,2,1-<i>de</i>]phenanthridin-8-ones via Pd(OAc)<sub>2</sub>‑Catalyzed Double Oxidative Coupling Dehydrogenations
收藏NIAID Data Ecosystem2026-05-02 收录
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A Pd(OAc)2-catalyzed self-coupling reaction of 2-bromo-N-arylbenzamides has been developed under basic conditions and in the presence of benzoic acid, unexpectedly producing 8H-indolo[3,2,1-de]phenanthridin-8-ones. The protocol involves Ullmann coupling and two consecutive oxidative coupling dehydrogenation steps, providing an efficient route for the production of fused pentacyclic indolophenanthridinone scaffolds with moderate to good yields.
创建时间：
2025-06-11
