Epigenome analysis of schwannomas arising as part of segmental schwannomatosis due to somatic mosaic SOX10 indel mutations

Genome-wide DNA methylation profiling of 6 schwannomas arising as part of segmental schwannomatosis due to somatic mosaic SOX10 indel mutations. The Illumina Infinium EPIC 850k Human DNA Methylation Beadchip was used to obtain DNA methylation profiles across approximately 850,000 CpG sites of genomic DNA extracted from formalin-fixed, paraffin-embedded tumor tissue of 6 schwannomas. Bisulfite converted genomic DNA extracted from the 6 schwannoma tumor samples was hybridized to Illumina Infinium EPIC 850k Human DNA Methylation Beadchips. Patient #1 is UCSF segmental schwannomatosis #1 and has four tumor samples labeled a, b, c, and d. Patient #2 is UCSF segmental schwannomatosis #2 and has two tumor samples labeled a and b.