Induction of trophoblast stem cells from human pluripotent stem cells
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2021-08-17
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The trophectoderm acts as a niche for the inner cell mass through IL-6 signaling [reprogramming_embryo]. The trophectoderm acts as a niche for the inner cell mass through IL-6 signaling [reprogramming_embryo]
IL-6 has been shown to be required for somatic cell reprogramming into induced pluripotent stem cells (iPSCs). However, how the cytokine is regulated and if it plays a role during embryo development r
NIAID Data Ecosystem50
Transcription factor NKX3-1 is required for reprogramming to pluripotency and can replace OCT4 in mouse and human iPSC induction [ATAC-seq]. Homo sapiens
Resolution of early molecular events preceding endogenous OCT4 activation is critical to understanding the mechanism of reprogramming somatic cells to induced pluripotent stem cells (iPSCs), yet captu
NIAID Data Ecosystem40
α-Ketoglutarate inhibits the pluripotent-to-totipotent state transition
In early mouse embryogenesis, the distinct enrichment of α-ketoglutarate (αKG) in blastocysts and L-2-hydroxyglutarate (L-2HG) in 2-cell (2C) embryos serves as a key metabolic signature. While elevate
NIAID Data Ecosystem30
Differentiation time course of trophoblast stem cells. Mus musculus
To characterized the changes in gene expression during the differentiation of TS cells. TS cells can be derived from two time point during embryogenesis, cell lines tested were from each of these time
NIAID Data Ecosystem50
Chromatin Accessibility Dynamics during Chemical Induction of Pluripotency [RNA-seq]. Chromatin Accessibility Dynamics during Chemical Induction of Pluripotency [RNA-seq]
Chemical induction of pluripotency (CIP) is an ideal way to reprogram cell fate, but remains poorly understood. Here we report the development of an efficient CIP protocol and the chromatin accessibil
NIAID Data Ecosystem40
