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Therapeutic targeting of myeloid leukemias with spliceosomal mutations through modulation of splicing catalysis

ChEBI2016-03-31 更新2026-07-12 收录

肿瘤靶向治疗

RNA剪接调控

数据链接：

https://www.ebi.ac.uk/biostudies/ArrayExpress/studies/E-GEOD-74064 数据链接链接失效反馈

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资源简介：

Therapeutic targeting of myeloid leukemias with spliceosomal mutations through modulation of splicing catalysis

应用场景：

创建时间：

2016-03-31

肿瘤靶向治疗

药物耐药机制

Protein arginine methyltransferase 5 (PRMT5) over-expression in hematological and solid tumors methylates arginine residues on cellular proteins involved in important cancer functions including cell c

NIAID Data Ecosystem90

A Wnt-induced lncRNA-DGCR5 splicing switch drives tumor-promoting inflammation in esophageal squamous cell carcinoma. Yue Li et al.

RNA剪接调控

食管鳞癌

Uncropped gel images in the Figures of this study

Mendeley Data10

Depletion of the E3 ubiquitin ligase HUWE1 impairs Kras-induced lung adenocarcinoma tumorigenesis and induces a senescent phenotype

肺腺癌分子机制

肿瘤靶向治疗

The E3 ubiquitin ligase HUWE1 modifies a diverse network of substrate proteins by ubiquitination, through which it regulates various intracellular processes and contributes to both oncogenic and tumou

NIAID Data Ecosystem00

Pharmacologic modulation of RNA splicing enhances anti-tumor immunity.. Pharmacologic modulation of RNA splicing enhances anti-tumor immunity.

RNA剪接调控

肿瘤免疫治疗

Although mutations in DNA are the best-studied source of neoantigens that determine response to immune checkpoint blockade, alterations in RNA splicing within cancer cells could similarly result in ne

NIAID Data Ecosystem50

Supplementary Table S2 from Activation of MET via Diverse Exon 14 Splicing Alterations Occurs in Multiple Tumor Types and Confers Clinical Sensitivity to MET Inhibitors

MET外显子14突变

肿瘤靶向治疗

Summary of MET exon 14 alterations.

NIAID Data Ecosystem10