Fusobacterium nucleatum Reducing METTL3-mediated m6A Modification Contributes to Colorectal Cancer Aggressiveness [RNA-Seq]

Transcriptome profiling revealed that KIF26B was associated with cell-cell junction and response to growth factor stimulation, which are important for CRC cell aggressiveness. And gene set enrichment analysis suggested that Hippo signaling pathway was significantly enriched in KIF26B-regulated gene signatures KIF26B induced gene expression in HCT116 colorectal cancer cells were measured at 48 h after transfection with siRNA control or siRNAs targeting KIF26B.