Transcriptome analysis of p16/p21-dependent monocytic myeloid-derived suppressor cells accumulation.
收藏干细胞与再生医学数据中心2022-02-20 更新2024-03-06 收录
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资源简介：
p16 and p21 act as tumor suppressors through induction of cellular senescence. However, senescence-independent roles of these CDK inhibitors are not known. To identify the mechanism responsible for the failure of Mo-MDSCs (monocytic myeloid-derived suppressor cells) infiltration into tumor allografts in p16/p21-double knockout (DKO) mice, we searched for chemokine receptors that were highly expressed in Mo- but not PMN-MDSCs (polymorphonuclear myeloid-derived suppressor cells) and were downregulated in p16/p21-DKO as compared to WT Mo-MDSCs. Ccr2, Ccr5, and Cx3cr1 were identified by RNA-seq analysis.
提供机构：
Research institute for microbial diseases, Osaka university
创建时间：
2022-02-20
