Dataset on the metabolome and the gut microbiota in mice after heatstroke

Heatstroke (HS) can trigger cytokine storm and multiple organ dysfunctions, but its pathophysiological mechanisms are complex and remain incompletely understood. Herein we explored the potential mechanisms on HS-driven inflammatory responses from the perspective of the gut microbiota-metabolite axis. In this dataset, the metabolic profiles of intestinal contents, serum, liver and cortex in mice after HS were analyzed by using an untargeted LC-MS-based metabolomics method. Moreover, the gut microbiota was analyzed via 16S rRNA gene sequencing in the intestinal contents of mice after HS or HS mice after treatment with an arginine-enriched oral inulin hydrogel.