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Tissue DNA methylation during SIVmac infection in the rhesus macaque

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NIAID Data Ecosystem2026-05-02 收录
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https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE226899
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We characterized DNA methylation profiles across lentiviral infection in a progressing non-human primate model of AIDS - SIVmac infection in the rhesus macaque. We contrasted methylation data across the course of the SIVmac infection in the young adult and old adult rhesus macaques to identify potential age-related differential methylation patterns and epigenetic clock acceleration. DNA methylation profiles were generated from 56 tissue samples from 6 solid tissues (cerebellum, transverse colon, liver, heart, spleen, and peritoneal fat) from 6 old adults and 4 young adults. For DNA methylation analysis, we used a custom Infinium methylation array HorvathMammalMethylChip40.
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2025-07-30
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