Single-cell transcriptomic profiling reveals a metabolic aspect of non-apoptosis in inherited retinal degeneration

The aim of this study was to provide deeper insight into the complex network of molec-ular and cellular changes that underlie inherited retinal degeneration by systematically mapping the transcriptional changes that occur in the degenerating mouse retina. Overall design: Rd1 and C3H wild type mice at different time points of P11(n = 3; Retina n = 6), P13 (n = 3; Retina n = 6) and P17 (n = 3; Retina n=6) were sacrificed regardless of gender for single cell RNA-sequencing (scRNA-seq) to profile the impact of rd1 mutation during mouse retina development.