Evaluation of transcriptomic regulations behind metabolic syndrome in obese and lean subjects

The study aimed to investigate molecular signatures in peripheral blood of individuals affected by metabolic syndrome (MetS) and different degrees of obesity. Metabolic health of 1204 individuals was assessed, and 32 subjects were recruited to four study groups: MetS lean, MetS obese, “healthy obese” and healthy lean. Whole-blood transcriptome next generation sequencing with functional data analysis was carried out. Overall design: Whole-blood transcriptome next generation sequencing of 32 human samples, with the use of Illumina NextSeq500.