RAW DATA; Table A. Lung Mechanics (Raw Data).

EST,L–Lung Static Elastance, ΔP1,L—Resistive Pressure, ΔP2,L -Viscoelastic Pressure. Control group (C) instilled with sterile saline and Silicosis group (SIL) instilled with silica particle. Fourteen days after disease induction, the animals were randomized to receive a solution of dimethyl sulfoxide (DMSO 1% in saline solution, 100 μL), dasatinib (DAS 1 mg/kg body weight in DMSO 1%, 100 μL) or saline (SAL, 100 μL). Table B. Lung and granuloma morphometry and inflammation (Raw Data). Granuloma Fraction (%),Granuloma Cellularity—Mononuclear Cells (%), Granuloma Cellularity—Neutrophils (%), Lung tissue protein levels of IL-1β Lung tissue protein levels of TNF-α Control group (C) instilled with sterile saline and Silicosis group (SIL) instilled with silica particle. Fourteen days after disease induction, the animals were randomized to receive a solution of dimethyl sulfoxide (DMSO 1% in saline solution, 100 μL), dasatinib (DAS 1 mg/kg body weight in DMSO 1%, 100 μL) or saline (SAL, 100 μL). Table C. Lung Morphometry and Differential Cell Count (Raw Data). Normal Alveoli (%), Collapsed Area (%), Hyperinflation (%), Neutrophils (%), Mononuclear Cells (%), Total Cells (%). Control Group (C) instilled with sterile saline and Silicosis group (SIL) instilled with silica particle. Fourteen days after disease induction, the animals were randomized to receive a solution of dimethylsulfoxide (DMSO 1% in saline solution, 100 μL), dasatinib (DAS 1mg/kg body weight in DMSO 1%, 100 μL) or saline (SAL, 100 μL). Table D. Quantification of total macrophages (F4/80 positive cells—Raw Data). F4/80 positive cells in lung parenchyma, F4/80 positive cells in silicotic granuloma. Control group (C) instilled with sterile saline and Silicosis group (SIL) instilled with silica particle. Fourteen days after disease induction, the animals were randomized to receive a solution of dimethyl sulfoxide (DMSO 1% in saline solution, 100 μL) or dasatinib (DAS 1 mg/kg body weight in DMSO 1%, 100 μL). Table E. Quantification of subtype M1 macrophages (iNOS positive cells—Raw Data). iNOS positive cells in lung parenchyma. iNOS positive cells in silicotic granuloma. Control group (C) instilled with sterile saline and Silicosis group (SIL) instilled with silica particle. Fourteen days after disease induction, the animals were randomized to receive a solution of dimethyl sulfoxide (DMSO 1% in saline solution, 100 μL) or dasatinib (DAS 1 mg/kg body weight in DMSO 1%, 100 μL). Table F. Quantification of subtype M2 macrophages (Arginase positive cells—Raw Data). Arginase positive cells in lung parenchyma, Arginase positive cells in silicotic granuloma. Control group (C) instilled with sterile saline and Silicosis group (SIL) instilled with silica particle. Fourteen days after disease induction, the animals were randomized to receive a solution of dimethyl sulfoxide (DMSO 1% in saline solution, 100 μL), dasatinib (DAS 1 mg/kg body weight in DMSO 1%, 100 μL). Table G. Fibrosis. Collagen fiber content in lung parenchyma (Raw Data). Collagen fiber content in silicotic granuloma. Control group (C) instilled with sterile saline and Silicosis group (SIL) instilled with silica particle. Fourteen days after disease induction, the animals were randomized to receive a solution of dimethyl sulfoxide (DMSO 1% in saline solution, 100 μL) or dasatinib (DAS 1 mg/kg body weight in DMSO 1%, 100 μL). Table H. In vitro Assay (Raw Data). mRNA levels of arginase, mRNA levels of iNOS, mRNA levels of MMP-9, mRNA levels of caspase-3. Control group (C) instilled with sterile saline and Silicosis group (SIL) instilled with silica particle. Fourteen days after disease induction, the animals were randomized to receive a solution of dimethyl sulfoxide (DMSO 1% in saline solution, 100 μL) or dasatinib (DAS 1 mg/kg body weight in DMSO 1%, 100 μL).
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