Loss of sarcolipin results in atrial remodeling. Mus musculus
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https://www.ncbi.nlm.nih.gov/bioproject/PRJNA131051
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资源简介：
Sarcolipin (SLN) is a key regulator of SERCA pump in atria. To determine the role of SLN in atrial Ca2+ homeostasis, we have generated a SLN null (sln-/-) mouse model. Ablation of SLN results in increased SR Ca2+ load and Ca2+ transients in atria. Further, loss of SLN results in electrophysiological and strcutural remodeling of atria. Overall design: The SLN knockout and C57/BL6 wildtype mice (each n=3) were selected for RNA extraction. The cRNA probes were hybridized to Affymetrix gene array.
创建时间：
2010-11-01
