DNA methylation of a novel regulatory element within the tyrosine hydroxylase gene (TH) is dysregulated by chronic cocaine dependence in the human striatum

This study investigates differences in DNA methylation that are associated with chronic cociane dependence in post-mortem nucleus accumbens tissue samples from human brain. The data were generated with reduced representation bisulfite sequencing (RRBS) and compared to data generated in accumbens tissue from psychiatrically healthy controls. Overall design: This study generated RRBS libraries from 25 males with a history of chronic cocaine dependence and cocaine toxicology at time of death, and 25 drug-naïve males. Each sample was sequenced at least twice and raw reads were pooled for each individual. Raw data files represent pooled sequencing reads for each individual.