Genome-wide DNA methylation profiling of Acute Myeloid Leukemia
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Genome-wide DNA methylation profiling of Acute Myeloid Leukemia
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2010-01-12
相关数据集
Table 5_Local Promoter Methylation Disorder algorithm reveals bidirectional epigenetic disruption in DNMT3A-mutated AML and predicts azacitidine treatment response.xlsx
BackgroundDNMT3A mutations occur in 20-25% of acute myeloid leukemia (AML) cases and are associated with poor prognosis, yet the epigenetic mechanisms underlying treatment response remain poorly under
NIAID Data Ecosystem80
Inhibitors of LSD1 target demethylase-independent activity to induce differentiation in acute myeloid leukemia [anti-H3K9 ac, anti-H3K27, RCOR1, SPI1, and MLL4 ChIP-Seq]. Inhibitors of LSD1 target demethylase-independent activity to induce differentiation in acute myeloid leukemia [anti-H3K9 ac, anti-H3K27, RCOR1, SPI1, and MLL4 ChIP-Seq]
To determine whether changes in histone modifications directly correlate with changes in transcription, THP1 AML cells were treated with a potent and selective LSD1 inhibitor (OG86, 250nM) and then su
NIAID Data Ecosystem60
Mechanistic insights into chromatin targeting by leukemic NUP98-PHF23 fusion
The dysregulation of plant homeodomain (PHD) fingers has been implicated in several human diseases, including cancer. In a subset of aggressive acute myeloid leukemia (AML), chromosomal translocations
NIAID Data Ecosystem50
Additional file 4: of Genome-wide methylomic analysis in individuals with HNF1B intragenic mutation and 17q12 microdeletion
Table S3. Probes that are significantly differentaly methylated in both of the separate group analyses (note that all probes are in the same direction in both analyses). (XLSX 19 kb)
Figshare2018-07-19 更新60
Supplementary Table 7 from Disruption of the MYC Superenhancer Complex by Dual Targeting of FLT3 and LSD1 in Acute Myeloid Leukemia
GO Analysis from Regions of Differential MOLM13 H3K27Ac CUT&Tag (6 Hours After Drug Treatment) Pileup at Enhancers and Promoters
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