Synthesis of α‑Trifluoromethylacrylates by Ligand-Free Palladium-Catalyzed Mizoroki-Heck Reaction

Efficient ligand-free
palladium catalyzed Mizoroki–Heck
reaction allowed the formation of trisubstituted α-trifluoromethylacrylates.
The reaction showed good chemical tolerance and furnished moderate
to excellent yields of reaction. Silver salt additive proved to be
essential for the reaction. The reaction has been then applied to
the formation of 3-trifluoromethyl coumarins and analogues of therapeutic
agents.