Blood analysis of Cln3Δex7/8 mice.

The subset of clinical chemistry and hematological parameters that were found to have genotype-specific differences in the screen are shown, with significantly different values indicated in bold. RBC count, which did not differ, is also shown. Each row of values represents an independent set of measurements. Data represent mean ± SEM. *pCln3+/Δex7/8) females was excluded as an outlier. Non-italicized values were determined at the German Mouse Clinic. Italicized values were determined at Massachusetts General Hospital on a separate cohort of mice. The ∼5–6 fL offset in MCV measurements between these sites, as well as the ∼6–7% offset in RDW measurements, are likely due to differences in the automated analyzers used. RBC = red blood cell count, MCV = mean corpuscular volume, Retic. = reticulocyte, RDW = red cell distribution width. Two separate samples from 9–10 mice per group (genotype/sex) were analyzed in the primary screen, and samples from an additional 3–8 mice per group (genotype/sex) were analyzed in follow-up screens.