Changes in the genome of Helicobacter suis after a 4 weeks mouse passage of a porcine Helicobacter suis strain. Influence of mouse passage on genome of Helicobacter suis

Mice were infected with a porcine Helicobacter suis strain (input strain) to evaluate the influence of mouse passage on the genome of Helicobacter suis. 4 Weeks after the infection mice were sacrified and 4 isolates of Helicobacter suis (output strains)were obtained. Whole genome analysis of the 4 isolates obtained after mouse-passage of porcine H. suis HS1 strain (HS1_O1, HS1_O2, HS1_O3 and HS1_O4) and the original porcine HS1_I1 isolate, showed that mouse-passage of H. suis did not result in major recombination events within the H. suis genome.