2-hydroxy-1,4-naphthoquinones with 3-alkyldiarylether groups: synthesis and Plasmodium falciparum inhibitory activity - Supplementary data

Synthesis of 4-hydroxyphenyl esters 20c and 20d General method for the synthesis of the phenoxyphenyl esters (22a-d) General method for the synthesis of the phenoxyphenyl acids (23a-d) Characterization of 3b, 3c, and 3g-j Ester reduction to synthesize 28a and 28b Carboxylic acid reduction to synthesize 2-(4-(4-fluorophenoxy)phenyl)ethan-1-ol (28c) Further information from the oxidation and reductive alkylation reactions to obtain 3h, 3i, and 3k Parasite culture and assay information References 1H and 13C NMR spectra for all compounds