Coordinated directionality is the key model parameter which replicates PIEZO1 reepithelialization phenotypes.

Top: Summary table of monolayer experimental results on normalized wound closure and wound edge length. See also Fig 1. Bottom: Summary table of simulation results, depicting the effect of model parameters on normalized wound closure and wound edge length. For model parameters, single cell parameters (retraction strength, retraction duration, inter-retraction duration and cell motility) are separated from parameters which come from collective cell settings (cell-cell adhesion and coordinated directionality). A “+” indicates the wound feature is positively correlated with the model parameter, e.g., wound edge length increases with increased retraction strength, whereas “−” indicates a negative correlation, e.g., normalized wound closure is reduced with increasing retraction strength. Bolded italicized text denotes model parameters which correspond with experimental trends. See also Fig 2G and 2H and S3 Fig.