MAU2-independent loading of cohesin and protective mechanism against early truncating mutations in NIPBL. Homo sapiens strain:HEK293
收藏NIAID Data Ecosystem2026-03-11 收录
下载链接：
https://www.ncbi.nlm.nih.gov/bioproject/PRJNA574410
下载链接
链接失效反馈官方服务：
资源简介：
In cells with the predicted fatal out-of-frame single nucleotide duplication c.39dup in NIPBL the use of an alternative translation initiation site yields expression of an N-terminally truncated NIPBL that cannot interact with MAU2 and dramatically reduced MAU2 levels. Remarkably, this protective mechanism allows nearly normal amounts of cohesin to be loaded onto chromatin.
创建时间：
2019-09-26
