The inhibition of inner mitochondrial fusion in hepatocytes reduces non-alcoholic fatty liver and improves metabolic profile during obesity by modulating bile acid conjugation

Hepatocyte OPA1 deficiency protects mice from the development of metabolic syndrome by reducing lipid absorption from the diet. OPA1 deficiency affects bile acid conjugation as a consequence of reduced mitochondria-peroxisome-ER tethering. Comparative gene expression profiling analysis of RNA-seq data in CTRL and OPA1 hepatocyte KO mouse liver