Supplementary Table S17 from A Functional Survey of the Regulatory Landscape of Estrogen Receptor–Positive Breast Cancer Evolution

Supplementary Table S17: Downstream analyses considering only the SIDV inferred genetic alterations with predicted impact on function and stratifying them by cancer-cell fraction (CCF) increase and decrease in metastatic samples. S17.1: summary of the results of the statistical tests performed to identify differences in the predicted impact of mutations stratified by change in CCF in metastatic samples compared to matched primary. The fraction of variants predicted as pathogenic and either showing an increase or a decrease in CCF (+- 0.1) was compared to that of those showing no change. P-values for the indicated features are shown (Chi-squared test). S17.2: similarly, the distribution of the predicted molecular effects of variants in the three groups (increase, decrease or no change in CCF) were compared using the Kruskal-Wallis test. S17.3: like S13.3 but testing for the enrichment of mutations with both computationally predicted pathogenic effects and a certain CCF increase or decrease in metastatic samples, that also show a certain behavior in SIDP.