Transcriptomic study of heart tissue from diabetic cardiomyopathy mice

To explore the key genes involved in spontaneous diabetic cardiomyopathy, db/db and BKS mice were used to examine the differently expressed genes in the related progresses. Briely, the heart transcriptome of db/db and BKS mice was correlated with the heart function, cardiomyocyte ultrastructure and histopathology characters. Two murine strains with C57BL/6 background were used in this study. Db/db group was used as the spontaneous diabetic cardiomyopathy group, and the BKS group was used as the healthy control group. Both groups of mice were housed under standard conditions with food and water provided without limitation and maintained on a 12 hour light/12 hour dark cycle. Body weight and food consumption were recorded every other day.