JLP interacts with CDO complex

JLP is a scaffold protein for the p38 MAPK pathway. During myogenic differentiation JLP binds the intracellular region of CDO which in turn binds p38 leading to p38 activation. The major CDO-binding region of JLP resides between amino acids 465-647.

JLP作为一种支架蛋白，对于p38 MAPK通路发挥着至关重要的作用。在肌原性分化过程中，JLP与CDO的细胞内区域相结合，而CDO随后与p38结合，进而导致p38的激活。JLP的主要CDO结合区域位于氨基酸465至647之间。