Investigation of a Flexible Enantiospecific Approach to Aziridines

A flexible approach to functionalized and enantioenriched
aziridines has been developed from an intermediate aziridinylmethyl tosylate. This protocol features a Cu-catalyzed
Grignard substitution reaction that allows a range of functionalized organic fragments to be incorporated. Moreover,
a convenient one-pot procedure is outlined that allows the
trityl group to be exchanged for a range of common
N-protecting groups.