Hs27-CRISPRa-TFs
收藏Zenodo2025-05-14 更新2026-05-26 收录
下载链接：
https://zenodo.org/doi/10.5281/zenodo.15200179
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资源简介：
Processed dataset of all transcription factor CRISPRa perturbations within Hs27 cells (fibroblasts) from:
Comprehensive transcription factor perturbations recapitulate fibroblast transcriptional states
Southard KM, Ardy RC, Tang A, O'Sullivan DD, Metzner E, Guruvayurappan K, Norman TM. Comprehensive transcription factor perturbations recapitulate fibroblast transcriptional states. bioRxiv [Preprint]. 2024 Aug 3:2024.07.31.606073. doi: 10.1101/2024.07.31.606073. PMID: 39131349; PMCID: PMC11312553.
in press at Nature Genetics
Raw fastq files available at SRA: PRJNA1108254
This record contains aggregated, quality control filtered, and processed outputs downstream of cellranger including.
1) guide umis per cell: fibroblast_CRISPRa_aggr_total_guide_umis.h5
2) final qc filtered population with multiplets: fibroblast_CRISPRa_final_pop.h5ad
3) filtered singlets, processed with scanpy.pp.normalized_total and scanpy.pp.log1p. Raw counts saved in layer['counts']: fibroblast_CRISPRa_final_pop_singlets_normalized_log1p.h5ad
4) "mean" population constructed from the full regression model from overloaded droplets: fibroblast_CRISPRa_mean_pop.h5ad
提供机构：
Zenodo
创建时间：
2025-05-14
