Crystal structure of the first bromodomain of human BRD4 in complex with the dual inhibitor TW12
收藏Protein Data Bank Japan2024-01-24 更新2026-03-21 收录
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Crystal structure of the first bromodomain of human BRD4 in complex with the dual inhibitor TW12 Descriptor: (S)-N1-(4-(2-(4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)acetamido)phenyl)-N8-hydroxyoctanediamide, 1,2-ETHANEDIOL, Bromodomain-containing protein 4 Authors: Joerger, A.C, Balourdas, D.I, Weiser, T, Chatterjee, D, Knapp, S, Structural Genomics Consortium (SGC) Deposit date: 2020-04-17 Release date: 2020-05-06 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (1.07 Å) Cite: Characterization of a dual BET/HDAC inhibitor for treatment of pancreatic ductal adenocarcinoma. Int.J.Cancer, 147, 2020
创建时间：
2020-04-17
