Multivariable Cox regression models for OS and RFS in 349 NPM1-mutated patients.

White blood cell count, platelet count, hemoglobin level, lactase dehydrogenase level, bone marrow blasts, de novo AML versus non de novo AML, performance status, sex, age, type A versus rare type NPM1 mutation, FLT3-ITD, monoallelic CEBPA mutations, biallelic CEBPA mutations were included in the Cox regression models for OS and RFS with backward elimination. The analyses were performed using 313 patients for OS and 227 RFS who had data for all these variables. A p-value of NPM1 mutation type.Abbreviations: CEBPA, CCAAT/enhancer-binding protein alpha gene; CI, confidence interval; FLT3-ITD, internal tandem duplication of the FLT3 gene; HR, hazard ratio; negative, absence of FLT3-ITD; NPM1, nucleophosmin gene; NPM1-A, mutation in the nucleophosmin gene leading to the insertion of the tetranucleotide TCTG; NPM1-RA, mutation in the nucleophosmin gene other than type A; OS, Overall survival; p, p value; positive, presence of FLT3-ITD; RFS, Relapse-free survival; WBC, white blood cell count.Multivariable Cox regression models for OS and RFS in 349 NPM1-mutated patients.