A comprehensive analysis of the faecal microbiome and metabolome of Strongyloides stercoralis infected volunteers from a non-endemic area

In this study, we explore the impact of sole, natural infections by the human parasite Strongyloides stercoralis on the faecal gut microbiota and metabolic profiles of a cohort of human volunteers from northern Italy (S+), pre- and post-anthelmintic treatment, and compare the findings with data obtained from a cohort of uninfected controls from the same geographical area (S-). The collected data was obtained through high-throughput sequencing of bacterial 16S rRNA using an Illumina Miseq and nuclear magnetic resonance (NMR) and gas chromatography - mass spectrometry analyses of raw faecal samples.

The data set includes four types of files:

Raw joined read files - 1 per sample (demultiplexed): e.g. S+pre-treatment1.fasta

OTU table created using Qiime including all of the taxonomic information: OTU_table.biom

A table containing the metabolite quantification from the NMR and GC-MS analyses. These tables have been normalised to total area: Metabolomic_data_NMR_GC-MS_nomalised_to_total_area.xlsx

Metadata file containing the relevant contextual information for each sample: Supplementary table S1.xlsx