Adverse Outcome Pathway on inhibition of calcineurin activity leading to impaired T‑cell dependent antibody response
收藏Organisation for Economic Co-operation and Development2026-04-11 收录
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https://www.oecd.org/en/publications/adverse-outcome-pathway-on-inhibition-of-calcineurin-activity-leading-to-impaired-t-cell-dependent-antibody-response_3c988dde-en.html
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The present AOP describes the inhibition of calcineurin activity resulting in impaired T-Cell Dependent Antibody Response (TDAR). Calcineurin (CN), a protein phosphatase, is known to impair immune function when its phosphatase activation is inhibited. CN inhibitors (CNIs) inhibit CN phosphatase activity to suppress many kinds of immune functions...
