Estimated of tMRCA for Genotype F, with Whole genome, polymerase and PreC-Core fragments of Panamanian samples.

tMRCA calculated by calibration with a fixed substitution mean rate (1.5 E-5) and time-stamped data under the best-fit demographic model indicated by the log-marginal likelihood analysis (appendix, S3). The Bayesian analysis was performed for the HBV whole genome, and a portion (876 pb) of polymerase gene from the available sequences (databases available upon request). The years correspond to dates in the past.*substitutions/site/year.