HNF4a Mediated Formation of Hepatic Progentiors [array expression data set]

HNF4a has been shown to be a central regulator of hepatocyte differentiation and function in adult mice. It was recently shown the HNF4a regulates the onset of hepatic gene expression during liver differentiation in vitro and is critical for the specification of liver towards a hepatic fate We examined the global gene expression of the differentiaiton of iPS cells into specified hepatic cells on consecutive days of liver differentiation (Mallanna et al 2013) to determine the onset of hepatic gene expression and the role HNF4a plays during hepatic specification. Performed gene array analyses on consecutive days of the differentiation of iPS cells into specified hepatic cells, days 3 - 8, in biological duplicate.