HG002 DNA (PacBio and ONT) and UHRR RNA (ONT) base modification data for minimod

Recent advances in third-generation sequencing technologies have enabled
the detection of various DNA and RNA base modifications in addition to
standard nucleotide sequences. Both major vendors in this space—Oxford
Nanopore Technologies (ONT) and Pacific Biosciences (PacBio)—now include
base modification information in their sequencing outputs using MM/ML tags
embedded in unaligned BAM files. Each vendor also provides dedicated tools
for extracting and analysing these tags, such as ONT’s modkit and PacBio’s
pb-cpg-tools. This work presents Minimod, a new vendor-agnostic tool
designed to extract and analyse any type of base modification from
sequencing data generated by any platform that supports MM/ML
tags. Minimod is a free, open-source application written in C and
is available in GitHub and Zenodo (see related works). This dataset
provides the supporting data used to evaluate Minimod’s performance.