Hemispheric divergence of interoceptive processing across psychiatric disorders

Interactions between top-down attention and bottom-up visceral inputs are assumed to produce conscious perceptions of interoceptive states, and while each process has been independently associated with aberrant interoceptive symptomatology in psychiatric disorders, the neural substrates of this interface are unknown. We conducted a preregistered functional neuroimaging study of 46 individuals with anxiety, depression, and/or eating disorders (ADE) and 46 propensity-matched healthy comparisons (HC), comparing their neural activity across two interoceptive tasks differentially recruiting top-down or bottom-up processing within the same scan session. During an interoceptive attention task, top-down attention was voluntarily directed towards cardiorespiratory or visual signals, whereas during an interoceptive perturbation task, intravenous infusions of isoproterenol (a peripherally-acting beta-adrenergic receptor agonist) were administered in a double-blinded and placebo-controlled fashion ..., Please refer to the \"Materials and Methods\" section of the manuscript for full description of data collection, processing, and analysis. , , # Hemispheric divergence of interoceptive processing across psychiatric disorders

[https://doi.org/10.5061/dryad.xgxd254rc](https://doi.org/10.5061/dryad.xgxd254rc)

## Description of the data and file structure

This dataset accompanies the following publication: Adamic et al. (2024) ([https://doi.org/10.7554/eLife.92820.2)](https://doi.org/10.7554/eLife.92820.2). Here we examined interoceptive neural processing using two different functional magnetic resonance imaging (fMRI) probes: bottom-up manipulation of cardiorespiratory signals, and top-down attention towards cardiac and respiratory sensations. Participants performed two tasks preferentially manipulating either bottom-up or top-down streams, respectively: 1) bottom-up cardiorespiratory stimulation via 2mcg infusion of isoproterenol, or a saline placebo in a double-blinded manner, or 2) top-down attention towards cardiorespiratory sensations during physiological rest (Visceral Interoceptive Attention task). Based on establishe...