Comparison of gene expression in the GAS M1T1 strain 5448, wild-type vs pepO mutant. Comparison of gene expression in the GAS M1T1 strain 5448, wild-type vs pepO mutant

Manuscript title: The endopeptidase PepO regulates the SpeB cysteine protease and is essential for the virulence of invasive M1T1 Streptococcus pyogenes. The study investigates the effect of pepO mutation on global gene expression in GAS M1T1 strain 5448. Overall design: Two-condition experiment, GAS M1T1 strain 5448 WT vs. pepO mutant. Biological replicates: 3, independently grown and harvested. One replicate of each strain per array.