Myriocin and rapamycin generate a synergistic increase in lifespan.

† Values represent the concentration of individual drugs necessary to produce the same degree of survival as the combination treatment and were calculated from dose response curves. ¶ Survival represents the fraction of cells viable after 48 hrs of incubation (CLS Day1) divided by the survival after a further 32 hrs of incubation. ‡ The drug combination (150 nM myriocin + 50 nM rapamycin = 60 ng/ml myriocin + 46 ng/ml rapamycin) shown in this row was used to generate the lifespan data shown in Fig. 1A and other experiments labeled with the term ComboDT. § Underlined values represent drug combinations in the corresponding row that give additive or antagonistic effects. Myriocin and rapamycin generate a synergistic increase in lifespan.