DBU-catalyzed Michael additions of bulky glycine imine to β-arylfuryl substituted α,β-unsaturated esters
收藏Taylor & Francis Group2023-08-23 更新2026-04-16 收录
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https://tandf.figshare.com/articles/dataset/DBU-catalyzed_Michael_additions_of_bulky_glycine_imine_to_-arylfuryl_substituted_-unsaturated_esters/23830979/1
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资源简介：
DBU-catalyzed Michael reactions between <i>tert</i>-butyl 2-((diphenylmethylene) amino)acetate and simple β-substituted α,β-unsaturated esters have been achieved in high yields (up to 95% yield) and diastereoselectivties (up to 99:1 dr) in the presence of 1.0 eq. of LiBr in acetonitrile under room temperature. The Michael adduct can be easily converted into <i>trans</i>-3-substituted pyroglutamic acid ester through <i>in-situ</i> acidic hydrolysis following lactamation.
提供机构：
Wang, Xue-Ying; Zhang, Sheng-Yong; Wang, Ping-An; Bai, Yu-Jun; Cheng, Mei-Ling; Bao, Guo-Qiang; Zhu, Si-Kai
创建时间：
2023-08-03
