Classification achieved using the disease risk score.

The TB/LTBI 27 transcript signature and TB/OD 44 transcript signature were applied to the South African/Malawi HIV-uninfected (HIV−) and HIV-infected (HIV+) test cohort and the independent validation dataset. Sensitivity and specificity calculated using the weighted threshold for classification. The actual numbers of patients that were DRS negative and positive are shown in Table S4.a99.94%.HIV−; HIV-uninfected; HIV+; HIV-infected; NA; not applicable.